New: CHRONOS - for CTC PAL samplers

CHRONOS controls PAL samplers in an efficient and intelligent way and enhances sample throughput considerably.

Most chromatographic or spectrometric investigation processes in the area of instrumental analysis are characterized by the use of autosamplers. The purpose of automation is to increase throughput without the need for additional personnel. Up to now, the samples have been worked through automatically in sequence. This means that with conventional machine control systems, waiting times frequently occur due to sample preparation during which the chromatographs are not used, offering considerable potential for throughput optimization. And it is precisely this potential which is utilized by CHRONOS. CHRONOS increases the active measuring time of the machines and therefore considerably raises the efficiency of the laboratory.

Parallel processes for sample preparation

The CHRONOS software organizes parallel processes for sample preparation. This utilizes the analysis system to a much greater extent, while observing the time margins of each individual sample preparation. To this is added further strengths of the software: a user-friendly interface minimizes the number of parameters which need to be changed depending on context. The relevant values are recorded in tabular form and can be changed by the user, which means that a complete sample list can be generated conveniently in only a few steps. Fixed parameters can be changed as needed in the method editor. (Fig.1 Section of window for creating sample lists related to context following selection of method)

A graphic representation of the sample processing is created at the touch of a button, which means that overall duration and current progress can be followed in real time. Multi-stage sample preparation procedures can be parallelized by means of an integrated algorithm. Here also, it is possible to call up a graphic representation of the sequence of events. CHRONOS also combines the sample list for the autosampler control with the data system list, so that the user only has to administrate one list. This simplifies handling and avoids errors which could be caused by confusing different items.

Applicable Hardware

  • Control of multiple PALs including PAL RTC and available PAL Options
  • Support of DualPAL systems
  • Support of Balances from Mettler Toledo
  • Support of liner exchange in a GL Sciences Linex system
  • Support of Anton Paar Abbemat Refractometer
  • Support of Gilson dilutors for sample dilutions
  • Support of SPME fiber changer
  • Support of ITEX functions
  • Support of 2D Barcode Reader from Axel Semrau
  • Control of peristaltic pumps for liquid handling
  • Support of IKA-Shaker
  • Support of Bandelin Digitec Ultrasonic Bath
  • Support of ZPL Printer
  • Support of IKA RCT Heater/Stirrer plates

  • Programmability of Valco valves over a serial interface
  • Call up external programs for data interpretation from within the method
    reading of gravimetric data from a Mettler balance

All encompassing functionality

  • Management of multiple sample lists
  • Management of priority samples
  • Customizable sample list for easy user interface adjustments
  • Easy navigation through bundling of tasks
  • Comfortable functions to create task lists 
  • Free choice of units with helpful proposals
  • Simple cut/copy/paste functions
  • Automatic reports permit fast control
  • Optimized time sequence, especially in combination with the barcode reader
  • CSV import options, e.g. for LIMS integration
  • Simple PDF generation from the method
  • Access to xlsx files - in reading and editing mode
  • Improved keyboard control within the sample list
  • Extended printing options and improved printout of sample lists
  • Ability to send SMS messages
  • Interfaces to many external software packages

Applicable Chromatography and MS Data Systems

  • Sciex Analyst 1.41 and higher
  • Bruker MS Workstation 8.2
  • Waters MassLynx 4.1
  • Thermo Omnic 9
  • Agilent Masshunter B07, B06 (GC)
  • Agilent Masshunter LC
  • DataAppex Clarity Vs. 3.0 and higher
  • Shimadzu Labsolutions
  • Chromperfect 6.0.1 and higher
  • GL Sciences Evolution Workstation
  • Thermo Xcalibur 1.4 up to, LC and GC
  • Agilent Chemstation, GC, LC and MSD
  • Open Lab Chemstation C01.06 und C01.07
  • EZChrom Vs. 3.21 and higher

  • Import and export of sequences in ChemStation and Xcalibur or cvs-format
  • Direct integration in LIM-Systems from ICD

Updates are easy to implement, existing methods can be transferred in a simple and safe way.

Examples of applications

GC and GC/MS

  • Headspace
  • SPME
  • ITEX-2
  • Derivatization
  • automatic H53 extraction
  • online SPE
  • DualPAL applications


  • Multi-dimensional chromatography
  • Matrix separation using SPE
  • Derivatization with fluorescence tags
  • Fast separation of active ingredients in pharmaceutical research


CHRONOS is supplied with ready-made modules for standard analysis procedures by default; this includes headspace, liquid injection, SPME and other standardized methods such as hydrocarbon determination according to DIN H53. If required, the user can generate additional modules in CHRONOS adapted to his own needs. PAL series autosamplers from CTC Analytics and OEM products of the same design are currently supported.

Xcalibur from Thermo Scientific, ChemStation from Agilent and Analyst are integrated. Linking to further data systems as EZChrom is in process.

Axel Semrau® has developed CHRONOS in cooperation with the University of Bochum. 2011, Axel Semrau® and CTC Analytics signed a contract for a long-term development cooperation agreement. The combination of professional programmers, IT specialists and experienced chemists who are in close contact to customers is the key for a practical solution of highest quality. The software and solutions based on CHRONOS and Sample Control will be provided and maintained all over the world by Axel Semrau® and the distribution partners of CTC Analytics.

Please contact us for a web presentation or a demo version of this unique software solution.

Sample Status Screenshot

Method Editor


Data sheets

weitere Informationen

Website of the manufacturer